Simulate
Individualise
Drug:
ATG
Carbamazepine
Clobazam
Clonazepam
Dexmedetomidine
Fraxiparin
Gentamycin
Lamotrigine
Levetiracetam
Lithium
Lorazepam
Manual
Oxcarbazepine
Phenobarbital
Phenytoin
Tobramycin
Topiramate
Valproate
Vancomycin
Zonisamide
Number of compartments:
One
Two
Three
Dosing type and route:
Single
Multiple
Steady-state
Bolus
Infusion
Oral
Parameter values:
Absorption constant (h):
0.1
10
0
0
3
0.1
1.1
2.1
3.1
4.1
5.1
6.1
7.1
8.1
9.1
10
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Clearance (L/h):
0.1
20
0
0
2
0.1
2.1
4.1
6.1
8.1
10.1
12.1
14.1
16.1
18.1
20
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Central volume of distribution (L/kg):
0.1
100
0
0
1
0.1
10
20
30
40
50
60
70
80
90
100
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Intercomp. Clearance 1->2 (h):
0.1
10
0
0
1.5
0.1
1.1
2.1
3.1
4.1
5.1
6.1
7.1
8.1
9.1
10
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Peripheral volume of distribution 2 (L/kg):
0.1
10
0
0
3
0.1
1.1
2.1
3.1
4.1
5.1
6.1
7.1
8.1
9.1
10
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Intercomp. Clearance 1->3 (h):
0.1
10
0
0
1.5
0.1
1.1
2.1
3.1
4.1
5.1
6.1
7.1
8.1
9.1
10
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Peripheral volume of distribution 3 (L/kg):
0.1
10
0
0
3
0.1
1.1
2.1
3.1
4.1
5.1
6.1
7.1
8.1
9.1
10
Variance (%):
0
100
0
0
20
0
10
20
30
40
50
60
70
80
90
100
Therapeutic concentration range:
-
Dose:
mg
mg/kg
Over:
Hours
Days
Every:
hours
days
Amount in:
mg
mg/kg
Time in:
hours
days
Simulate time for:
1
24
0
0
12
1
4
7
10
13
16
19
22
24
Hours
Days
Comedication:
Carbamazepine
mg/day
mg/kg/day
Phenobarbital
mg/day
mg/kg/day
Phenytoin
mg/day
mg/kg/day
Valproate
mg/day
mg/kg/day
Zonisamide
mg/day
mg/kg/day
Number of patients:
1
1,000
0
0
100
1
101
201
301
401
501
601
701
801
901
1,000
Age (years):
Weight (kg):
Baseline lymphocytes (x 10^9/L):
Generate typical population
Specify population
Adults (18-65 y)
Children (4-14 y)
Infants (0.25-3 y)
Neonates (0-1 m)
Non-obese
Obese
Age range (years):
-
Weight range (kg):
-
Baseline lymphocytes (x 10^9/L):
-
Time of transplantation in days
Cardiosurgery:
Yes
No
Ethnicity:
Asian
Black
Caucasian
Hispanic
Simulate!
Concentrations
Area Under the Curve
Model description
Drug:
Carbamazepine
Clobazam
Clonazepam
Gentamycin
Lamotrigine
Levetiracetam
Lithium
Lorazepam
Oxcarbazepine
Phenobarbital
Phenytoin
Tobramycin
Topiramate
Valproate
Vancomycin
Zonisamide
Dosing type and route:
Steady-state
Oral
Dose:
mg
mg/kg
Every:
hours
days
Simulate time for:
1
24
0
0
12
1
4
7
10
13
16
19
22
24
Hours
Days
Comedication:
Carbamazepine
mg/day
mg/kg/day
Phenobarbital
mg/day
mg/kg/day
Phenytoin
mg/day
mg/kg/day
Valproate
mg/day
mg/kg/day
Zonisamide
mg/day
mg/kg/day
Age (years):
Weight (kg):
Ethnicity:
Asian
Black
Caucasian
Hispanic
Estimate!